This exciting project aims to influence cancer cells metabolism through electrodes poised at specific potentials. Cancer cells display significantly altered metabolism, in particular regarding their respiration and fermentation pathways. Our hypothesis is that these changes in metabolism are caused by redox imbalances of the cells, and can therefore be understood or controlled through electrode-based perturbations of cellular redox systems. In this project, we will attempt to develop this approach for cancer cells by utilizing both direct and indirect electron transfer between cells and electrodes.
To deliver this project, we are looking to recruit two motivated individuals, with combined theoretical and experimental backgrounds, who can work as a team. We will be modelling the impact of perturbing redox-based control points in cancer metabolism and experimentally implement such perturbations by developing cell-electrode interfacing systems. After an initial stage of method development with yeast cells, we will focus on cancer cell lines.
Candidates are expected to have a theoretical/experimental education in biology, chemistry, physics, or engineering, and a relevant PhD experience. Skills in any, or all, of the following topics would be preferential: computational/biophysical modelling, bioelectrochemical system design and measurements, mammalian cell biology, and metabolic measurements.
Please see here for further particulars and application details. For specific questions, you can also get in touch directly with Prof. Soyer.
We have a 3-yrs PhD studentship open to EU and UK applicants. The specific project for this position is being developed, but in general we are looking for candidate with a strong motivation to undertake independent research and a background in biology, physics, chemistry, mathematics, engineering, or computer science. Candidates with cross disciplinary backgrounds and experiences are particularly encouraged to apply. For specific questions, please get in touch directly with Prof. Soyer.
We are actively looking for postdoctoral researchers to join the lab. We are particularly interested in projects that combine applied synthetic biology approaches with our interest in evolutionary systems biology and could support fellowship applications in these directions (see fellowships provided by various sources such as EPSRC, Royal Society, and Wellcome Trust). To discuss please get in touch with Orkun Soyer with a CV and cover letter detailing your interests: