Articles

48. Cooperation in microbial communities and their biotechnological applications.

Matteo Cavaliere, Song Feng, Orkun S. Soyer, Jose I. Jimenez
Environmental Microbiology in press.
PDF

47. Metabolic modelling in an evolutionary framework predicts adaptive diversification of bacteria in a long-term evolution experiment.

Tobias Grosskopf, Jessika Consuegra, Joel Gaffe, John C. Willison, Richard E. Lenski, Orkun S. Soyer, and Dominique Schneider
BMC Evolutionary Biology 16(1):163 (2016).
PDF | Resource 12 (evoFBA)

46. A stable genetic polymorphism underpinning microbial syntrophy.

Tobias Grosskopf, Simone Zenobi, Mark Alston, Leighton Folkes, David Swarbreck, and Orkun S Soyer
The ISME Journal 10:12 (2016)
PDF | Sequence Data |

45. Core signalling motif displaying multistability through multi-state enzymes.

Song Feng, Meritxell Sez, Carsten Wiuf, Elisenda Feliu, and Orkun S. Soyer
Royal Society Interface 13:123 (2016).
PDF

44. Enzyme Sequestration as a Tuning Point in Controlling Response Dynamics of Signalling Networks

Song Feng, Julien F. Ollivier, and Orkun S. Soyer
PLoS Computational Biology 12(5):e1004918 (2016).
PDF | Resource 11

43. Microbial diversity arising from thermodynamic constraints.

Tobias Grosskopf and Orkun S. Soyer
The ISME Journal 10:11 (2016)
PDF | Resource 10

42. Challenges in microbial ecology: building predictive understanding of community function and dynamics.

Stefanie Widder, Rosalind Allen, Thomas Pfeiffer, Thomas P. Curtis, Carsten Wiuf, William T. Sloan, Otto X. Cordero, Sam P. Brown, Babak Momeni, Wenying Shou, Helen Kettle, Harry J. Flint, Andreas F. Haas, Batrice Laroche, Jan-Ulrich Kreft, Paul B. Rainey, Shiri Freilich, Stefan Schuster, Kim Milferstedt, Jan R. van der Meer, Tobias Grosskopf, Jef Huisman, Andrew Free, Cristian Picioreanu, Christopher Quince, Isaac Klapper, Simon Labarthe, Barth F. Smets, Harris Wang, Isaac Newton Institute Fellows*, and Orkun S. Soyer
The ISME Journal 10:11 (2016)
PDF | In "top download list" at ISME website.

41. Ultrasensitive Negative Feedback Control: A Natural Approach for the Design of Synthetic Controllers.

Francesco Montefusco, Ozgur E. Akman, Orkun S. Soyer, and Declan Bates
PLoS One 18;11(8):e0161605 (2016).
PDF

40. Mapping epigenetic changes to the host cell genome induced by Burkholderia pseudomallei reveals pathogen-specific and pathogen-generic signatures of infection.

Deniz Cizmeci, Emma L. Dempster, Olivia L. Champion, Sariqa Wagley, Ozgur E. Akman, Joann L. Prior, Orkun S. Soyer, Jonathan Mill, and Richard W. Titball
Scientific Reports 6:30861 (2016).
PDF

39. Nonlinear dynamics in gene regulation promote robustness and evolvability of gene expression levels

Arno Steinacher, Declan G. Bates, Ozgur E. Akman, and Orkun S. Soyer
PLoS One 11(4):e0153295 (2016)
PDF

38. BioJazz: in silico evolution of cellular networks with unbounded complexity using rule-based modeling

Song Feng, Julien Ollivier, Peter S. Swain, and Orkun S. Soyer
Nucleic Acid Research 43(19):e123 (2015).
PDF | BioJazz | Resource 9

37. Unlimited multistability and Boolean logic in microbial signaling

Varun B. Kothamachu, Elisenda Feliu, Luca Cardelli, and Orkun S. Soyer
Royal Society Interface 12:108 (2015).
PDF

36. Engineering and biology: Counsel for a continued relationship

Brett Calcott, Arnon Levy, Mark L. Siegal, Orkun S. Soyer, and Andreas Wagner.
Biological Theory 10(1):50-59 (2015)
PDF

35. A philosophical perspective on evolutionary systems biology.

Maureen A. O'Malley, Orkun S. Soyer, and Mark L. Siegal.
Biological Theory 10(1):6-17 (2015).
PDF

34. Phosphate sink containing two-component signaling systems as tunable threshold devices.

Munia Amin, Varun B. Kothamachu, Elisenda Feliu, Birgit E. Scharf, Steven L. Porter, and Orkun S. Soyer
PLoS Computational Biology 10(10):e1003890 (2014).
PDF

33. Bacterial drug tolerance under clinical conditions is governed by anaerobic adaptation, but not anaerobic respiration.

Claudia M. Hemsley, Jamie X. Luo, Clio A. Andreae, Clive S. Butler, Orkun S. Soyer, and Richard W. Titball
Antimicrobial Agents and Chemotherapy 58(10):5775-83 (2014).
PDF

32. Synthetic microbial communities.

Tobias Grosskopf and Orkun S. Soyer
Current Opinion in Microbiology 18:72-77 (2014).
PDF | In "top download list" at Current Opinion in Microbiology website.

31. Phosphorelays provide tunable signal processing capabilities for the cell.

Varun B. Kothamachu, Elisenda Feliu, Carsten Wuif, Luca Cardelli, and Orkun S. Soyer
PLoS Computational Biology 9(11):e1003322 (2013).
PDF

30. Systems and synthetic biology underpinning biotechnology.

Orkun S. Soyer and Peter Swain
Current Opinion Biotechnology 24(4):735-6 (2013).

29. Evolutionary Systems Biology: What it is and why it matters.

Maureen O'Malley and Orkun S Soyer
BioEssays 35(8):696-705 (2013).

28. Metabolic Tinker: An online tool for guiding the design of synthetic metabolic pathways.

Kent McClymont and Orkun S. Soyer
Nucleic Acid Research 41(11):e113 (2013).
PDF | Tinker | Resource 8

27. Split histidine kinases enable ultrasensitivity and bistability in two-component signaling networks.

Amin Munia, Steve Porter, and Orkun S. Soyer
PLoS Computational Biology 9(3): e1002949 (2013).
PDF |

26. Bistability in feedback circuits as a byproduct of evolution of evolvability.

Hiroaki Kuwahara and Orkun S Soyer
Molecular Systems Biology 8:564 (2012).
PDF | Resource 7 | In "top download list" at Nature MSB website.

25. Evolutionary principles underlying structure and response dynamics of cellular networks.

Arno Steinacher and Orkun Soyer
Advances in Experimental Medicine and Biology 751 (2012).

24. The roles of integration in molecular systems biology.

Maureen A. O'Malley and Orkun S. Soyer
Studies in History and Philosophy of Biological and Biomedical Sciences 43:1 (2012).
PDF | In "top download list" at ScienceDirect subject website.

23. Evolution of response dynamics underlying bacterial chemotaxis.

Orkun S. Soyer and Richard A. Goldstein
BMC Evolutionary Biology 11:240 (2011).
PDF

22. The promise of evolutionary systems biology: Lessons from bacterial chemotaxis.

Orkun S. Soyer
Science Signaling 3:128, pe23 (2010).
PDF

21. Duplicate retention in signaling proteins and constraints from network dynamics.

Chris J. Creevey and Orkun S. Soyer
Journal of Evolutionary Biology 23:11 (2010).
Abstract | Resource 6

20. Response dynamics of phosphorelays suggest their potential utility in cell signaling.

Attila Csiksz-Nagy, Luca Cardelli, and Orkun S. Soyer
Journal of Royal Society Interface 8:57 (2010).
PDF | Resource 5

19. Evolution under fluctuating environments explains observed robustness in metabolic networks.

Orkun S. Soyer and Thomas Pfeiffer
PLoS Computational Biology 6(8): e1000907 (2010).
PDF

18. Fate of a duplicate gene in a network context.

Orkun S. Soyer
Invited chapter in "Evolution After Gene Duplication", Dittmar K., Liberles D.A. (eds.) Wiley and Sons, ISBN: 978-0-470-59382-0, October 2010.
Book Description

17. Regulating the total level of a signaling protein can vary its dynamics in a range from switch like ultrasensitivity to adaptive responses.

Orkun S. Soyer, Hiroaki Kuwahara, and Attila Csiksz-Nagy
FEBS Journal, 276:12 (2009).
Abstract

16. Evolution of taxis responses in bacteria: nonadaptive dynamics.

Richard A. Goldstein and Orkun S. Soyer
PLoS Computational Biology, 4:5, e1000084 (2008).
PDF | Resource 3, 4

15. Parasites lead to evolution of robustness against gene loss in host signaling networks.

Marcel Salathe and Orkun S. Soyer
Molecular Systems Biology, 4:202 (2008).
PDF | Resource 2 | Featured in Nature | Top ten download at Nature MSB website.

14. Adaptive dynamics with a single two state protein.

Attila Csiksz-Nagy and Orkun S. Soyer
Royal Society Interface, 5:Suppl 1, S41-7 (2008).
PDF

13. Evolving BlenX programs to simulate the evolution of biological networks.

Lorenzo Dematte, Corado Priami, Alfonso Romanel, and Orkun S. Soyer
Theoretical Computer Science, 408:1 (2008).
PDF

12. Emergence and maintenance of functional modules in signaling pathways.

Orkun S Soyer
BMC Evolutionary Biology, 7:205 (2007).
PDF

11. A formal and integrated framework to simulate evolution of biological pathways.

Lorenzo Dematte, Corado Priami, Alfonso Romanel, and Orkun S. Soyer
Proceedings of the Fifth International Conference on Computational Methods in Systems Biology (CMSB) 106-120 (2007).

10. Evolution of complexity in signaling pathways.

Orkun S. Soyer and Sebastian Bonhoeffer
Proc. Natl. Acad. Sci. USA (PNAS), 103:44 (2006).
PDF

9. Simulating the evolution of signal transduction pathways.

Orkun S Soyer, Thomas Pfeiffer, and Sebastian Bonhoeffer
Journal of Theoretical Biology, 241:2 (2006).
PDF

8. Signal transduction networks: topology, response, and biochemical reactions.

Orkun S. Soyer Marcel Salathe, and Sebastian Bonhoeffer
Journal of Theoretical Biology, 238:2 (2006).
PDF | Resource 1

7. Evolution of connectivity in metabolic networks.

Thomas Pfeiffer, Orkun S. Soyer, and Sebastian Bonhoeffer
PLoS Biology, 3:7 (2005).
PDF | Featured in Journal of Cell Biology

6. Predicting functional sites in proteins: Site specific evolutionary models and their application to neurotransmitter transporters.

Orkun S. Soyer and Richard A. Goldstein
Journal of Molecular Biology, 339:1 (2004).

5. Probing conformational changes in neurotransmitter transporters in a structural context.

Naomi R. Goldberg, Thijs Beuming, Orkun S. Soyer, Richard A. Goldstein, Harel Weinstein, and Jonathan A. Javitch
European Journal of Pharmacology, 479:1-3 (2003).

4. Dimerization in aminergic G-protein coupled receptors: Application of a hidden site-class model of protein evolution.

Orkun S. Soyer, Matt W. Dimmic, Richard R. Neubig, and Richard A. Goldstein
Biochemistry, 42:49 (2003).

3. Depict a proteins two faces: Using phylogenetic tree based HMMs for G-protein coupled receptor classification.

Bin Qian, Orkun S. Soyer, Richard R. Neubig, and Richard A. Goldstein
FEBS Letters, 554:1-2 (2003).

2. NMR Structure of the second intracellular loop of the alpha2a adrenergic receptor: Evidence for a novel cytoplasmic helix.

Duane A. Chung, Erik R. P. Zuiderweg, Carol B. Fowler, Orkun S. Soyer, Henry I. Mosberg, and Richard R. Neubig
Biochemistry, 41:11 (2002).

1. Using evolutionary methods to study G-protein coupled receptors.

Orkun S. Soyer, Matt W. Dimmic, Richard R. Neubig, and Richard A. Golstein
Pacific Symposium on Biocomputing (PSB) 625-36 (2002).