Postdoctoral and PhD positions
We are actively looking for postdoctoral researchers and PhD students to join the lab. We are particularly interested in projects that combine applied synthetic biology approaches with our interest in evolutionanry systems biology.
To apply please get in touch with Orkun Soyer with a CV and cover letter detailing your interests;
PhD Studentship on "Host-Virus metabolic modelling"
This project builds on our expertise in analysing viral infection of host cells through a unique approach that treats the virus-infected cell as a single metabolic system. Using phage infection of E.coli cells as a model system, we have pioneered this approach and developed a modified version of the flux balance analysis (FBA) to analyse the impact of perturbations on host and virus. This modified version of FBA draws inspiration from the study of co-evolutionary dynamics and pathogen-mediated interference of the host, which we have significant experience in studying through in silico evolution approaches. In this project, we will further develop the modified FBA approach and combine it with kinetic modelling of metabolism, dynamic FBA and in silico evolution to study virus infections. The outcome of the modelling component will be the prediction of alterations (over-, under-expression) in host enzyme levels. These will then feed into an experimental pipeline that will be used to study the effect of predicted perturbations on viral growth. The experimental work will be conducted by our collaborators at DSTL.
To apply, please visit here.